Machine learning student

Wow, you aren't going to approach what you want here on that budget. There might be a few Intel mobos somewhere that are already offering PCIe 4, but way out of the price range here. AMD is the only way to go right now for that.

Sample this (edited for brevity):


Digital Storm Desktop - Config ID 3034070     
1
$4,096.00     $4,096.00
     
System Configuration:
Chassis Model: Digital Storm Lumos
Exterior Finish: - Standard Factory Finish
Processor: AMD Ryzen 9 3900X (12-Core) 4.6 GHz Turbo
Motherboard: ASUS ROG Strix X570-E Gaming (Wi-Fi) (AMD X570 Chipset) (Up to 3x PCI-E Devices)
System Memory: 64GB DDR4 3200MHz Digital Storm Performance Series
Power Supply: 1000W Digital Storm Performance Series (Fully Modular) (80 Plus Gold)
Storage Set 1: 1x SSD M.2 (512GB Samsung 970 PRO) (NVM Express)
Storage Set 2: 1x Storage (2TB Seagate / Toshiba / Hitachi)
Storage Set 3: - No Thanks
Internet Access: High Speed Network Port (Supports High-Speed Cable / DSL / Network Connections)
Graphics Card(s): 1x GeForce RTX 2080 Ti 11GB (VR Ready)
Sound Card: Integrated Motherboard Audio
HPC Processor: - No Thanks
Extreme Cooling: H20: Stage 2: Digital Storm Vortex Liquid CPU Cooler (Dual Fan) (Fully Sealed + No Maintenance)
Cable Management: Premium Cable Management (Strategically Routed & Organized for Airflow)
Chassis Fans: Standard Factory Chassis Fans
Internal Lighting: - No Thanks
Airflow Control: - No Thanks
CPU Boost: Stock Factory Turbo Boost Advanced Automatic Overclocking
Graphics: - No Thanks, Please do not overclock my video card(s)
OS Boost: - No Thanks, Please do not tweak the services on the operating system
Operating System: Microsoft Windows 10 Home (64-Bit Edition)
Recovery Tools: USB Drive - Windows 10 Installation (Format and Clean Install)
Virus Protection: Windows Defender Antivirus (Built-in to Windows 10)
Priority Build:- No thanks, 6 Week Ship Estimate After Order Is Successfully Processed
Warranty: Life-time Expert Care with 3 Year Limited Warranty (3 Year Labor & 1 Year Part Replacement)

141815     -- PROMOTIONAL LIMITED TIME BONUS DISCOUNT: $400     1     ($400.00)     ($400.00)


The Proc is the $500 part you asked for.

The Mobo is the cheapest you can go for 128GB RAM capable and is PCIE 4.

-64GB RAM; -SLI capable PSU; -Samsung 970 PRO; -2080 Ti.

This is bare bones what you are asking. I would recommend the Corsair LL Series or the ML PRO series for the "good cooling scheme" but no room in the budget.

I would also assume you'd rather opt for Windows 10 Pro, but I left that out.

The budget killer here is the 2080 Ti, but I understand the RTXs have some kind of machine learning chops I do not know how you might use.

To view this in the configurator, go to the DS main page. In the upper right, you'll see "Load Config". Copy and paste the DS Config ID, number only, and paste it in the window that opens. Play around with all the options and see what you can do.